{"id":166,"date":"2014-04-15T08:26:48","date_gmt":"2014-04-15T08:26:48","guid":{"rendered":"http:\/\/www.altmann.eu\/research\/?p=166"},"modified":"2014-07-15T06:54:08","modified_gmt":"2014-07-15T06:54:08","slug":"paper-published-in-annals-of-neurology","status":"publish","type":"post","link":"http:\/\/www.altmann.eu\/research\/?p=166","title":{"rendered":"Paper published in Annals of Neurology"},"content":{"rendered":"<p>Our paper was published in <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.24135\/abstract\">Annals of Neurology<\/a>!<\/p>\n<p>Click <a href=\"http:\/\/med.stanford.edu\/ism\/2014\/april\/dementia.html?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+NewsFromStanfordsSchoolOfMedicine+%28News+from+Stanford%27s+School+of+Medicine%29&amp;utm_content=FeedBurner+user+view\">here<\/a> for Stanford&#8217;s Press release.<\/p>\n<p>Title: <strong>Sex modifies the APOE-related risk of developing Alzheimer disease<\/strong><\/p>\n<p>Abstract:<\/p>\n<p>Objective<br \/>\nThe APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD). Case\u2013control studies suggest the APOE4 link to AD is stronger in women. We examined the APOE4-by-sex interaction in conversion risk (from healthy aging to mild cognitive impairment (MCI)\/AD or from MCI to AD) and cerebrospinal fluid (CSF) biomarker levels.<\/p>\n<p>Methods<br \/>\nCox proportional hazards analysis was used to compute hazard ratios (HRs) for an APOE-by-sex interaction on conversion in controls (n = 5,496) and MCI patients (n = 2,588). The interaction was also tested in CSF biomarker levels of 980 subjects from the Alzheimer&#8217;s Disease Neuroimaging Initiative.<\/p>\n<p>Results<br \/>\nAmong controls, male and female carriers were more likely to convert to MCI\/AD, but the effect was stronger in women (HR = 1.81 for women; HR = 1.27 for men; interaction: p = 0.011). The interaction remained significant in a predefined subanalysis restricted to APOE3\/3 and APOE3\/4 genotypes. Among MCI patients, both male and female APOE4 carriers were more likely to convert to AD (HR = 2.16 for women; HR = 1.64 for men); the interaction was not significant (p = 0.14). In the subanalysis restricted to APOE3\/3 and APOE3\/4 genotypes, the interaction was significant (p = 0.02; HR = 2.17 for women; HR = 1.51 for men). The APOE4-by-sex interaction on biomarker levels was significant for MCI patients for total tau and the tau-to-A\u03b2 ratio (p = 0.009 and p = 0.02, respectively; more AD-like in women).<\/p>\n<p>Interpretation<br \/>\nAPOE4 confers greater AD risk in women. Biomarker results suggest that increased APOE-related risk in women may be associated with tau pathology. These findings have important clinical implications and suggest novel research approaches into AD pathogenesis<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our paper was published in Annals of Neurology! Click here for Stanford&#8217;s Press release. Title: Sex modifies the APOE-related risk of developing Alzheimer disease Abstract: Objective The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD). Case\u2013control studies suggest the APOE4 link to AD is stronger in women. We examined the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-166","post","type-post","status-publish","format-standard","hentry","category-research","entry"],"_links":{"self":[{"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=\/wp\/v2\/posts\/166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=166"}],"version-history":[{"count":2,"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=\/wp\/v2\/posts\/166\/revisions"}],"predecessor-version":[{"id":168,"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=\/wp\/v2\/posts\/166\/revisions\/168"}],"wp:attachment":[{"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=166"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.altmann.eu\/research\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}