here<\/a>!<\/p>\nSummary:
\nIn this study, we use an experimental imaging\u2013genetics approach for investigating the genetic underpinnings of brain atrophy in Alzheimer\u2019s disease. We successfully combined state-of-the-art imaging\u2013genetics methods and experimental gene expression data to uncover biology in brain atrophy. The experimental paradigm highlighted a significant role of tribbles pseudokinase 3 (TRIB3<\/em>) in modulating the typical pattern of Alzheimer\u2019s brain pathology. This result corroborates through rigorous data-driven statistical methods evidence emerging from previous studies about the role of TRIB3 in modulating known mechanisms of neurodegeneration, such as neuronal death, cellular homeostasis, and interaction with established genes causing autosomal dominant Alzheimer\u2019s disease: APP and PSEN1. The developed integrated statistical\u2013experimental methodology could serve as a roadmap for investigations in other disorders.<\/p>\n